Mitochondria Play an Unexpected Role in Killing Bacteria

The energy-producing organelles also send out parcels with antimicrobial compounds to help destroy pathogen invaders in macrophages. B.H. Abuaita et al., “Mitochondria-derived vesicles deliver antimicrobial reactive oxygen species to control phagosome-localized Staphylococcus aureus,” Cell Host Microbe, 24:625–36, 2018. According to biology textbooks, a macrophage engulfs a bacterium, internalizes it in a toxin-filled vesicle called a … More Mitochondria Play an Unexpected Role in Killing Bacteria

Probiotics Prevent Cholera in Animal Models

Two different types of bacteria—one genetically engineered and one from cheese—defend animal intestines from Vibrio cholerae infection. Following any vaccination, there is normally a delay of a week or two before protection kicks in, during which time the immune system is gearing up its adaptive response. But a potential new cholera vaccine—created by genetically engineering … More Probiotics Prevent Cholera in Animal Models

Uncovering more options in cancer immunotherapy

High throughput screening platform for small molecules. If scientists want to boost immune cells’ ability to kill cancer cells, then vast libraries of small molecules are potentially available. A new paper shows a platform to sort through them, plus validation. One of the hits: IAP antagonist birinapant, which is already in clinical trials (coincidentally). To … More Uncovering more options in cancer immunotherapy

Powerful microscope captures first image of nanoscaffold that promotes cell movement

Discovery could yield insights into cancer metastasis, wound healing, organ development and more cell-motility-related conditions Using one of the most powerful microscopes in the world, scientists have identified a dense, dynamic and disorganized actin filament nanoscaffold — resembling a haystack — that is induced in response to a molecular signal. This is the first time … More Powerful microscope captures first image of nanoscaffold that promotes cell movement